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Melanotan IIPreclinical / animal evidence

Melanocortin agonist

A synthetic cyclic analog of alpha-MSH researched for skin tanning and secondarily appetite and sexual function; not approved, with notable safety concerns.

⚙️ How it works

A non-selective melanocortin agonist (MC1R, MC3R, MC4R, MC5R). At skin MC1R it raises cAMP and the PKA-CREB-MITF pathway to drive eumelanin (tanning); centrally MC3R/MC4R suppress appetite and stimulate arousal. It crosses the blood-brain barrier.

🎯 What it's studied to help

Bars reflect the strength & volume of research evidence for each use — not a guarantee of results.

Skin55/100
Stimulates MC1R-driven melanogenesis, increasing pigmentation (tanning).
Libido45/100
Central MC3R/MC4R agonism promotes arousal — the precursor effect that led to PT-141.
Central melanocortin activation suppresses appetite in animals; human weight data are minimal.

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⚠️ Educational research information only — not medical advice. Many peptides are sold strictly for laboratory research and are not approved treatments. The evidence scores reflect research interest and strength, not efficacy or safety for any individual. Always consult a qualified professional.