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Home › Peptide library › Kisspeptin

KisspeptinClinical evidence

Reproductive neuropeptide

The master upstream regulator of the reproductive (HPG) axis, researched for fertility/IVF, hypothalamic amenorrhea and sexual/emotional brain processing.

⚙️ How it works

Binds the GPR54 (KISS1R) receptor on hypothalamic GnRH neurons (Gq/PLC, calcium release), stimulating pulsatile GnRH and downstream LH/FSH and sex hormones. In humans it also enhances sexual and emotional brain processing and reduces sexual aversion — a neuroendocrine 'primer'.

🎯 What it's studied to help

Bars reflect the strength & volume of research evidence for each use — not a guarantee of results.

Libido55/100
Enhances sexual brain processing and reduces aversion via HPG-axis priming, shown in human fMRI studies.
Modulates limbic/emotional regions and reduces negative emotional processing in imaging studies.
Restoring sex-hormone signalling is theorised to support vitality, but this is indirect.

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⚠️ Educational research information only — not medical advice. Many peptides are sold strictly for laboratory research and are not approved treatments. The evidence scores reflect research interest and strength, not efficacy or safety for any individual. Always consult a qualified professional.