A C-terminal tripeptide of alpha-MSH researched as an orally active anti-inflammatory for gut and skin inflammation.
Enters cells (in the gut largely via the PepT1 transporter) and acts intracellularly, not via surface melanocortin receptors. Stabilises IkB-alpha and inhibits IkB kinase, blocking nuclear translocation of NF-kB p65 and sharply reducing pro-inflammatory cytokines.
Bars reflect the strength & volume of research evidence for each use — not a guarantee of results.
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⚠️ Educational research information only — not medical advice. Many peptides are sold strictly for laboratory research and are not approved treatments. The evidence scores reflect research interest and strength, not efficacy or safety for any individual. Always consult a qualified professional.