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Peptides studied for gut & digestion

Gut-focused research peptides are studied for the GI lining, the intestinal barrier and inflammation — relevant to ulcers, leaky gut and inflammatory-bowel research.

1

Larazotide

Tight-junction regulator

Phase 2 trials cut celiac symptomatic days; note the Phase 3 trial was discontinued in 2022 for small effect size.

2

Semaglutide

GLP-1 agonist

Slows gastric emptying and modulates gut-brain signalling (also the source of GI side effects).

3

BPC-157

Body Protection Compound

Protects and heals GI mucosa and supports gut-barrier integrity in ulcer, colitis and fistula models.

4

Tirzepatide

GLP-1 / GIP agonist

Delays gastric emptying and modulates appetite signalling.

5

KPV

Alpha-MSH tripeptide

Orally delivered KPV reduces severity of DSS- and TNBS-induced colitis in mice.

6

Retatrutide

Triple-agonist

Incretin arms slow gastric emptying and increase satiety.

⚠️ Educational research information only — not medical advice. Many peptides are research-use-only and not approved treatments. Always consult a qualified professional.