A mitochondrial-derived peptide researched as an 'exercise mimetic' for insulin sensitivity, metabolic health and aging — largely in animals.
Encoded within mitochondrial 12S rRNA; inhibits the folate cycle to raise AICAR and activate AMPK, the master energy sensor. AMPK activation promotes glucose uptake, fatty-acid oxidation and mitochondrial biogenesis; also raises NAD+ with partial SIRT1 involvement.
Bars reflect the strength & volume of research evidence for each use — not a guarantee of results.
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⚠️ Educational research information only — not medical advice. Many peptides are sold strictly for laboratory research and are not approved treatments. The evidence scores reflect research interest and strength, not efficacy or safety for any individual. Always consult a qualified professional.