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RetatrutideClinical (Phase 2) evidence

Triple-agonist

An investigational GLP-1/GIP/glucagon triple agonist (Lilly) producing the largest weight loss recorded for an anti-obesity drug.

⚙️ How it works

Activates three receptors: GLP-1 and GIP reduce appetite, slow gastric emptying and improve insulin handling, while the added glucagon arm increases resting energy expenditure and hepatic fat mobilisation — lowering intake and raising burn.

🎯 What it's studied to help

Bars reflect the strength & volume of research evidence for each use — not a guarantee of results.

Phase 2 showed up to 24% body-weight loss at 48 weeks at the highest dose.
Glucagon-driven energy expenditure plus large liver-fat reductions; long-term data pending.
Incretin arms slow gastric emptying and increase satiety.

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⚠️ Educational research information only — not medical advice. Many peptides are sold strictly for laboratory research and are not approved treatments. The evidence scores reflect research interest and strength, not efficacy or safety for any individual. Always consult a qualified professional.